Brand  (β version)

PDB ID: 3SH9

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Ligands
Code Name Style Show Link
CEF Cefotaxime, c3' cleaved, open, bound form PoSSuM
BB0 1-[6-(dimethylamino)naphthalen-2-yl]ethanone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3SH9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/ANTIBIOTIC
Title : Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime
Release Data : 2011-07-27
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A,B Penicillinase
ec: 3.5.2.6
fragment: Small exopenicillinase
mutation: E166C
Source :
mol_id organism_scientific expression_system
1 Bacillus licheniformis  (taxid:1402) Escherichia coli  (taxid:562)
gene: penP
Authors : Wong, W.-T., Zhao, Y.-X., Leung, Y.-C.
Keywords : PenP, beta-lactamase, cefotaxime, fluorophore, HYDROLASE-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics

Wong, W.-T.,Chan, K.-C.,So, P.-K.  et al.
(2011)  J.Biol.Chem.  286 : 31771 - 31780

PubMed: 21705325
DOI: 10.1074/jbc.M110.198895

Reaction

Chain : A, B
UniProt : P00808 (BLAC_BACLI)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE-ProRule:PRU10101
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