Het-PDB Navi2 (PDB: 3SC0)

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Ligands
Code	Name		Style	Show	Link
COB	Co-methylcobalamin				PoSSuM

Non-standard Residues
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Glycosylation
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Modification
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Download interaction data: 3SC0

Code :

3SC0 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with MethylCobalamin

Release Data :

2011-06-22

Compound :

mol_id	molecule	chains
1	Methylmalonic aciduria and homocystinuria type C protein	A
	fragment: B12 binding domain, Residues 1-238

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MMACHC expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pMCSG7

Authors :

Koutmos, M., Gherasim, C., Smith, J.L., Banerjee, R.

Keywords :

MMACHC, CblC, Cobalamin, Flavin, Glutathione, Flavin Reductase, Oxidoreductase, Maturase

Exp. method :

X-RAY DIFFRACTION ( 1.9500 Å )

Citation :

Structural basis of multifunctionality in a vitamin B12-processing enzyme.

Koutmos, M.,Gherasim, C.,Smith, J.L. et al.
(2011) J.Biol.Chem. 286 : 29780 - 29787

Chain :

UniProt :

Q9Y4U1 (MMAC_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 cyanocob(III)alamin + 2 apo-[cyanocobalamin reductase] + NADPH + H(+)	1.16.1.6	PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485
	right-to-left	PubMed:19700356
apo-[alkylcobalamin reductase] + an R-cob(III)alamin + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S- substituted glutathione + H(+)	2.5.1.151	PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485
	left-to-right	PubMed:25809485
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)	2.5.1.151	PubMed:19801555, PubMed:22642810, PubMed:25809485
	left-to-right	PubMed:25809485
apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)	2.5.1.151	PubMed:19801555
	left-to-right	PubMed:19801555
Cofactor:	Evidence:	Note:
FMN	ECO:0000269 \| PubMed:19700356 ECO:0000269 \| PubMed:21697092 ECO:0000269 \| PubMed:19700356 ECO:0000269 \| PubMed:21697092	Can utilize both FAD and FMN.

PDB ID: 3SC0