Brand  (β version)

PDB ID: 3SAI

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
9DR 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
NI Nickel (II) ion PoSSuM
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Structure summary

Code : 3SAI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015
Release Data : 2012-06-13
Compound :
mol_id molecule chains
1 Dihydrofolate reductase A,B
ec: 1.5.1.3
mutation: I2R
Source :
mol_id organism_scientific organism_common expression_system
1 Bacillus anthracis  (taxid:1392) Anthrax,anthrax bacterium Escherichia coli  (taxid:562)
gene: BAS2083, BA_2237, dfrA, GBAA2237, GBAA_2237
expression_system_strain: M15
expression_system_vector_type: PLASMID
expression_system_plasmid: PQE2
Authors : Anderson, A.C., Beierlein, J.M.
Keywords : Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.2500 Å )
Citation :

SAR studies of heterocyclic propargyl-linked TMP analogs targeting Bacillus dihydrofolate reductase

Anderson, A.C.,Beierlein, J.M.,Viswanathan, K.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : Q81R22 (Q81R22_BACAN)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+) 1.5.1.3 PIRNR:PIRNR000194
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