Brand  (β version)

PDB ID: 3S91

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Ligands
Code Name Style Show Link
IPA Isopropyl alcohol PoSSuM
JQ1 (6s)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3S91   PDBj   RCSB PDB   PDBe
Header : UNKNOWN FUNCTION
Title : Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1
Release Data : 2011-06-29
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 3 A RING3-like protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRD3, KIAA0043, RING3L
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Picaud, S., Qi, J., Keates, T., Felletar, I., Fedorov, O., Muniz, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bradner, J.E., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : BRD3, Bromodomain containing protein 3, ORFX, RING3 like gene, RING3L, JQ1, Structural Genomics, Structural Genomics Consortium, SGC, UNKNOWN FUNCTION
Exp. method : X-RAY DIFFRACTION ( 2.0600 Å )
Citation :

Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1

Filippakopoulos, P.,Picaud, S.,Qi, J.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q15059 (BRD3_HUMAN)
Reaction : -