Het-PDB Navi2 (PDB: 3S0N)

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Ligands
Code	Name		Style	Show	Link
0BB	4-{3-[(4-methyl-1-benzothiophen-3-yl)methyl]-2-oxo-2,3-dihydro-1h-benzimidazol-1-yl}butanoic acid				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 3S0N

Code :

3S0N PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal Structure of Human Chymase with Benzimidazolone Inhibitor

Release Data :

2011-07-20

Compound :

mol_id	molecule	chains	synonym
1	Chymase	A	Alpha-chymase, Mast cell protease I
	ec: 3.4.21.39 fragment: UNP residues 22-247 mutation: F127K,V208A,R235Q

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CMA1, CYH, CYM expression_system_common: Fall armyworm expression_system_vector_type: BACULOVIRUS

Authors :

Qian, K.C., Farrow, N.A., Padyana, A.K.

Keywords :

SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.9500 Å )

Citation :

Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region.

Lo, H.Y.,Nemoto, P.A.,Kim, J.M. et al.
(2011) Bioorg.Med.Chem.Lett. 21 : 4533 - 4539

Chain :

UniProt :

P23946 (CMA1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Preferential cleavage: Phe-\|-Xaa > Tyr-\|-Xaa > Trp-\|-Xaa > Leu-\|-Xaa.	3.4.21.39	-
	-	-

PDB ID: 3S0N