Het-PDB Navi2 (PDB: 3RVF)

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Ligands
Code	Name		Style	Show	Link
034	5-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1h-indole-2-carboxylic acid				PoSSuM
SO4	Sulfate ion				PoSSuM

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Download interaction data: 3RVF

Code :

3RVF PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION REGULATOR

Title :

FXR with SRC1 and GSK2034

Release Data :

2011-09-21

Compound :

mol_id	molecule	chains	synonym
1	Bile acid receptor	A	FXR, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
	fragment: ligand binding domain (UNP residues 257-486)

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	B	SRC1, NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1
	ec: 2.3.1.48 fragment: UNP residues 741-761

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: BAR, FXR, HRR1, NR1H4, RIP14 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pRSETA

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Williams, S.P., Madauss, K.P.

Keywords :

nuclear receptor, alpha-helical sandwich, transcription factor, RXR, transcription co-factors, bile acid, farnesoid, TRANSCRIPTION REGULATOR

Exp. method :

X-RAY DIFFRACTION ( 3.10 Å )

Citation :

Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.

Akwabi-Ameyaw, A.,Caravella, J.A.,Chen, L. et al.
(2011) Bioorg.Med.Chem.Lett. 21 : 6154 - 6160

PDB ID: 3RVF