Brand  (β version)

PDB ID: 3RQD

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
Code Name Show
BB9 (2z)-2-amino-3-sulfanylprop-2-enoic acid
03Y 2-methyl-L-cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
02G (3s,4e)-3-hydroxy-7-sulfanylhept-4-enoic acid

Structure summary

Code : 3RQD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8
Release Data : 2011-08-24
Compound :
mol_id molecule chains synonym
1 Histone deacetylase 8 A,B HD8
ec: 3.5.1.98
mol_id molecule chains
2 Largazole C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HDAC8, HDACL1, CDA07
mol_id organism_scientific
2 Symploca  (taxid:105591)
synthetic: yes
Authors : Cole, K.E., Dowling, D.P., Christianson, D.W.
Keywords : histone deacetylase, largazole, histone deacetylation, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.143 Å )
Citation :

Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.

Cole, K.E.,Dowling, D.P.,Boone, M.A.  et al.
(2011)  J.Am.Chem.Soc.  133 : 12474 - 12477

PubMed: 21790156
DOI: 10.1021/ja205972n

Reaction

Chain : A, B
UniProt : Q9BY41 (HDAC8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone] 3.5.1.98 PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:28497810
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H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein] - PubMed:22885700
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H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein] - PubMed:28497810
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