Brand  (β version)

PDB ID: 3RIX

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Ligands
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923 (5z)-4-hydroxy-3-[(2r)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]-5-{[(2r)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-1-benzofuran-5-yl]methylidene}furan-2(5h)-one PoSSuM
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Structure summary

Code : 3RIX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : 1.7A resolution structure of a firefly luciferase-Aspulvinone J inhibitor complex
Release Data : 2011-12-07
Compound :
mol_id molecule chains synonym
1 Luciferin 4-monooxygenase A Luciferase
ec: 1.13.12.7
Source :
mol_id organism_scientific organism_common
1 Photinus pyralis  (taxid:7054) North American firefly
Authors : Lovell, S., Battaile, K.P., Lopez, P.C., Auld, D.S., Schultz, P.J., MacArthur, R., Shen, M., Tamayo, G., Inglese, J., Sherman, D.H.
Keywords : oxidoreductase, monooxygenase, photoprotein, luminescence, aspulvinone, natural product extracts, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7000 Å )
Citation :

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.

Cruz, P.G.,Auld, D.S.,Schultz, P.J.  et al.
(2011)  Chem.Biol.  18 : 1442 - 1452

PubMed: 22118678
DOI: 10.1016/j.chembiol.2011.08.011

Reaction

Chain : A
UniProt : P08659 (LUCI_PHOPY)
Reaction: EC: Evidence:
Physiological Direction:
ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu 1.13.12.7 UniProtKB:Q26304
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