Het-PDB Navi2 (PDB: 3RIE)

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Ligands
Code	Name	Link
MTA	5'-deoxy-5'-methylthioadenosine	PoSSuM
JFQ	Trans-N-(3-aminopropyl)cyclohexane-1,4-diamine	PoSSuM
GOL	Glycerol	PoSSuM

Non-standard Residues
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Download interaction data: 3RIE

Code :

3RIE PDBj RCSB PDB PDBe

Header :

transferase/transferase inhibitor

Title :

The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine

Release Data :

2012-04-25

Compound :

mol_id	molecule	chains
1	Spermidine synthase	A,B,C
	ec: 2.5.1.16 fragment: unp residues 41-321

Source :

mol_id	organism_scientific	expression_system
1	Plasmodium falciparum (taxid:36329)	Escherichia coli (taxid:469008)
	strain: 3D7 gene: PF11_0301 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: p15-TEV-LIC

Authors :

Williams, M., Sprenger, J., Persson, L., Louw, A.I., Birkholtz, L., Al-Karadaghi, S.

Keywords :

Rossmann-like fold, Rossmann Fold, spermidine synthesis, aminopropyl transferase, transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail.

Burger, P.B.,Williams, M.,Sprenger, J. et al.
(2015) Malar J 14 : 54 - 54

PDB ID: 3RIE