Brand  (β version)

PDB ID: 3RI5

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
IVM (2ae,4e,5'S,6s,6'R,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside PoSSuM
OCT N-octane PoSSuM
RI5 (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]C yclopropa[a]azulene-4,8(3h)-dione PoSSuM
UND Undecane PoSSuM
LMT Dodecyl-beta-D-maltoside PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 3RI5   PDBj   RCSB PDB   PDBe
Header : transport protein/immune system
Title : C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin
Release Data : 2011-05-25
Compound :
mol_id molecule chains
1 Avermectin-sensitive glutamate-gated chloride channel GluCl alpha A,B,C,D,E
mol_id molecule chains
2 Mouse monoclonal Fab fragment, heavy chain F,G,H,I,J
mol_id molecule chains
3 Mouse monoclonal Fab fragment, light chain K,L,M,N,O
Source :
mol_id organism_scientific organism_common expression_system
1 Caenorhabditis elegans  (taxid:6239) Nematode Spodoptera frugiperda  (taxid:7108)
gene: glc-1, F11A5.10
mol_id organism_scientific organism_common
2 Mus musculus  (taxid:10090) Mouse
cell: HYBRIDOMA
mol_id organism_scientific organism_common
3 Mus musculus  (taxid:10090) Mouse
cell: HYBRIDOMA
Authors : Hibbs, R.E., Gouaux, E.
Keywords : Membrane protein, transport protein, Cys-loop receptor, ligand-gated ion channel, neurotransmitter receptor, Ivermectin, Picrotoxin, Glycosylation, transport protein-immune system complex
Exp. method : X-RAY DIFFRACTION ( 3.4 Å )
Citation :

Principles of activation and permeation in an anion-selective Cys-loop receptor.

Hibbs, R.E.,Gouaux, E.
(2011)  Nature  474 : 54 - 60

PubMed: 21572436
DOI: 10.1038/nature10139

Reaction

Chain : A, B, C, D, E
UniProt : O17793
Reaction : -