Brand  (β version)

PDB ID: 3RFM

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Ligands
Code Name Style Show Link
CFF Caffeine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3RFM   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Thermostabilised adenosine A2A receptor in complex with caffeine
Release Data : 2011-09-07
Compound :
mol_id molecule chains
1 Adenosine receptor A2a A
fragment: residues 1-317
mutation: A54L, T88A, R107A, K122A, L202A, L235A, V239A, S277A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ADORA2A
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Hollenstein, K., Tehan, B., Hurrell, E., Bennett, K., Congreve, M., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Keywords : INVERSE AGONIST, 7TM, GPCR, SIGNALING PROTEIN, G-PROTEIN, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.598 Å )
Citation :

Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine

Dore, A.S.,Robertson, N.,Errey, J.C.  et al.
(2011)  Structure  19 : 1283 - 1293

PubMed: 21885291
DOI: 10.1016/j.str.2011.06.014

Reaction

Chain : A
UniProt : P29274 (AA2AR_HUMAN)
Reaction : -