PDB ID: 3R92
Hetero Atom Contents
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06J | (3ar)-13,13,16-trimethyl-15-oxo-1,2,3,3a,4,5,12,14,15,17,18,19-dodecahydro-13h-10,6-(metheno)pyrrolo[2',1':3,4][1,4,9]triazacyclotetradecino[9,8-a]indole-7-carboxamide | PoSSuM |
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Download interaction data: 3R92
Structure summary
Code : | 3R92 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | CHAPERONE/CHAPERONE INHIBITOR | ||||||||||||
Title : | Discovery of a macrocyclic O-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. | ||||||||||||
Release Data : | 2011-06-08 | ||||||||||||
Compound : |
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Authors : | Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Golas, J.M., Liu, H., Lucas, J., Boschelli, F., Vogan, E.M., Levin, J.I. | ||||||||||||
Keywords : | Chaperone, ATP binding domain, ATP-binding, Nucleotide-binding, Phosphoprotein, Stress response, CHAPERONE-CHAPERONE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.5801 Å ) | ||||||||||||
Citation : |
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Zapf, C.W.,Bloom, J.D.,McBean, J.L.
et al.
PubMed: 21605975 |
Reaction
Chain : | A | ||||||||
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UniProt : | P07900 (HS90A_HUMAN) | ||||||||
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