Brand  (β version)

PDB ID: 3R7Q

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Ligands
Code Name Style Show Link
FAV N-(2-chlorophenyl)-N-methyl-4h-thieno[3,2-C]chromene-2-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3R7Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure-based design of thienobenzoxepin inhibitors of PI3- kinase
Release Data : 2011-08-03
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform A PI3-kinase subunit gamma, PI3K-gamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p120-PI3K
ec: 2.7.1.153
fragment: unp residues 144-1102
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PIK3CG
expression_system_cell_line: Sf9
expression_system_vector_type: plasmid
Authors : Murray, J.M., Wiesmann, C.
Keywords : kinase p110, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.

Staben, S.T.,Siu, M.,Goldsmith, R.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 4054 - 4058

PubMed: 21636270
DOI: 10.1016/j.bmcl.2011.04.124

Reaction

Chain : A
UniProt : P48736 (PK3CG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 PubMed:11277933, PubMed:16123124
left-to-right PubMed:11277933
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 PubMed:15135396, PubMed:16123124, PubMed:31554793
left-to-right PubMed:15135396
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+) 2.7.1.154 PubMed:16123124
left-to-right
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12502714, PubMed:16094730
left-to-right PubMed:12502714