Brand  (β version)

PDB ID: 3R5Y

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Ligands
Code Name Style Show Link
F42 Coenzyme f420 PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3R5Y   PDBj   RCSB PDB   PDBe
Header : UNKNOWN FUNCTION
Title : Structure of a Deazaflavin-dependent nitroreductase from Nocardia farcinica, with co-factor F420
Release Data : 2012-01-18
Compound :
mol_id molecule chains
1 Putative uncharacterized protein A,B,C,D
Source :
mol_id organism_scientific expression_system
1 Nocardia farcinica  (taxid:37329) Escherichia coli  (taxid:562)
gene: NFA_33440
expression_system_vector_type: plasmid
expression_system_plasmid: SpeedET
Authors : Cellitti, S.E., Shaffer, J., Jones, D.H., Mukherjee, T., Gurumurthy, M., Bursulaya, B., Boshoff, H.I.M., Choi, I., Nayya, A., Lee, Y.S., Cherian, J., Niyomrattanakit, P., Dick, T., Manjunatha, U.H., Barry, C.E., Spraggon, G., Geierstanger, B.H.
Keywords : PA-824, nitroimidazoles, split barrel-like fold, DUF385, deazaflavin-dependent nitroreductase, F420, UNKNOWN FUNCTION
Exp. method : X-RAY DIFFRACTION ( 1.8010 Å )
Citation :

Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.

Cellitti, S.E.,Shaffer, J.,Jones, D.H.  et al.
(2012)  Structure  20 : 101 - 112

PubMed: 22244759
DOI: 10.1016/j.str.2011.11.001

Reaction

Chain : A, B, C, D
UniProt : Q5YUF0 (Q5YUF0_NOCFA)
Reaction: EC: Evidence:
Physiological Direction:
a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) - ARBA:ARBA00029371
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