Brand  (β version)

PDB ID: 3QWI

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
CUE Coumestrol PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3QWI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Crystal structure of a 17beta-hydroxysteroid dehydrogenase (holo form) from fungus Cochliobolus lunatus in complex with NADPH and coumestrol
Release Data : 2012-01-18
Compound :
mol_id molecule chains
1 17beta-hydroxysteroid dehydrogenase A,B,C,D
ec: 1.1.1.62
Source :
mol_id organism_scientific expression_system
1 Cochliobolus lunatus  (taxid:5503) Escherichia coli  (taxid:562)
strain: M118
gene: 17HSDcl
expression_system_strain: JM107
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX
Authors : Cassetta, A., Lamba, D., Krastanova, I., Stojan, J., Lanisnik Rizner, T., Kristan, K., Brunskole, M.
Keywords : 17BETA-HYDROXYSTEROID DEHYDROGENASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE, PHYTOESTROGENS, FLAVONOID, Rossmann Fold, Cytosol, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Structural studies on the flavonoid inhibition of a fungal 17Beta-Hydroxysteroid dehydrogenase

Cassetta, A.,Krastanova, I.,Kristan, K.  et al.
(2012)  Biochem.J.  441 : 151 - 160

PubMed: 21929506
DOI: 10.1042/BJ20110567

Reaction

Chain : A, B, C, D
UniProt : O93874 (O93874_COCLU)
Reaction : -