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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate
FCN Fosfomycin
Non-standard Residues
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Glycosylation
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Code : 3QUO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with ATP and fosfomycin
Release Data : 2011-07-20
Compound :
mol_id molecule chains
1 FomA protein A
Source :
mol_id organism_scientific expression_system
1 Streptomyces wedmorensis  (taxid:43759) Escherichia coli  (taxid:469008)
gene: fomA, fosfomycin resistance kinase
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Pakhomova, S., Bartlett, S.G., Doerner, P.A., Newcomer, M.E.
Keywords : fosfomycin, antibiotic resistance, phosphoryl transfer, kinase, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.58 Å )
Citation :

Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA.

Pakhomova, S.,Bartlett, S.G.,Doerner, P.A.  et al.
(2011)  Biochemistry  50 : 6909 - 6919

PubMed: 21728358
DOI: 10.1021/bi2004334

Chain : A
UniProt : Q56187 (Q56187_STRWE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate 2.7.4.26 ARBA:ARBA00000538
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