Brand  (β version)

PDB ID: 3QT8

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Ligands
Code Name Style Show Link
FM0 (3r)-3-(fluoromethyl)-3-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}pentanoic acid PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 3QT8   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Crystal structure of mutant S192A Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP
Release Data : 2011-05-11
Compound :
mol_id molecule chains synonym
1 Mevalonate diphosphate decarboxylase A,B Diphosphomevalonate decarboxylase
ec: 4.1.1.33
mutation: S192A
Source :
mol_id organism_scientific expression_system
1 Staphylococcus epidermidis  (taxid:1282) Escherichia coli  (taxid:562)
gene: mvaD
Authors : Barta, M.L., Skaff, A.D., McWhorter, W.J., Miziorko, H.M., Geisbrecht, B.V.
Keywords : GHMP kinase family, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.

Barta, M.L.,Skaff, D.A.,McWhorter, W.J.  et al.
(2011)  J.Biol.Chem.  286 : 23900 - 23910

PubMed: 21561869
DOI: 10.1074/jbc.M111.242016

Reaction

Chain : A, B
UniProt : Q9FD73 (Q9FD73_STAEP)
Reaction : -