Het-PDB Navi2 (PDB: 3QSD)

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Ligands
Code	Name	Link
074	[propylamino-3-hydroxy-butan-1,4-dionyl]-isoleucyl-proline	PoSSuM
ACT	Acetate ion	PoSSuM
PEG	Di(hydroxyethyl)ether	PoSSuM

Non-standard Residues
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Download interaction data: 3QSD

Code :

3QSD PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor

Release Data :

2011-08-10

Compound :

mol_id	molecule	chains	synonym
1	Cathepsin B-like peptidase (C01 family)	A	Cathepsin B1 isotype 1
	ec: 3.4.22.1 fragment: UNP residues 87-340 mutation: T168A, T283A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Schistosoma mansoni (taxid:6183)	Blood fluke	Pichia pastoris (taxid:4922)
	gene: cb1.1, Smp_103610 expression_system_strain: X33 expression_system_vector_type: plasmid expression_system_plasmid: pPICZalphaA

Authors :

Rezacova, P., Jilkova, A., Brynda, J., Horn, M., Mares, M.

Keywords :

cysteine peptidase, digestive tract, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.30 Å )

Citation :

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.

Jilkova, A.,Rezacova, P.,Lepsik, M. et al.
(2011) J.Biol.Chem. 286 : 35770 - 35781

PDB ID: 3QSD