Brand  (β version)

PDB ID: 3QH5

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Ligands
Code Name Style Show Link
0A9 Methyl L-phenylalaninate PoSSuM
CA Calcium ion PoSSuM
NX6 N-[(benzyloxy)carbonyl]-L-aspartic acid PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PG4 Tetraethylene glycol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3QH5   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structure of Thermolysin in complex with N-Carbobenzyloxy-L-aspartic acid and L-Phenylalanine Methyl Ester
Release Data : 2012-01-04
Compound :
mol_id molecule chains synonym
1 Thermolysin A Thermostable neutral proteinase
ec: 3.4.24.27
Source :
mol_id organism_scientific
1 Bacillus thermoproteolyticus  (taxid:1427)
Authors : Birrane, G., Bhyravbhatla, B., Navia, M.
Keywords : HYDROLASE, METALLOPROTEINASE, L-Phenylalanine Methyl Ester, N-Carbobenzyloxy-L-asparic acid, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.

Birrane, G.,Bhyravbhatla, B.,Navia, M.A.
(2014)  ACS MED.CHEM.LETT.  5 : 706 - 710

PubMed: 24944748
DOI: 10.1021/ml500101z

Reaction

Chain : A
UniProt : P00800 (THER_BACTH)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe. 3.4.24.27 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 4 Ca(2+) ions per subunit.
Zn(2+) - Binds 1 zinc ion per subunit.