PDB ID: 3QGT
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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CP6 | 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine | PoSSuM | |||
NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
UMP | 2'-deoxyuridine 5'-monophosphate | PoSSuM |
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Download interaction data: 3QGT
Structure summary
Code : | 3QGT PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE, TRANSFERASE/INHIBITOR | ||||||||||||
Title : | Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE | ||||||||||||
Release Data : | 2011-06-29 | ||||||||||||
Compound : |
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Source : |
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Authors : | Chitnumsub, P., Yuthavong, Y. | ||||||||||||
Keywords : | malarial DHFR-TS antifolate complex, rossmann fold, reductase, Dihydrofolate binding, dUMP binding, NADPH binding, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.3000 Å ) | ||||||||||||
Citation : |
Trypanosomal dihydrofolate reductase reveals natural antifolate resistance
Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J.
et al.
PubMed: 21650210 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | A7UD81 (A7UD81_PLAFA) | ||||||||||||
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