Het-PDB Navi2 (PDB: 3QFX)

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Ligands
Code	Name		Style	Show	Link
NDP	Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate				PoSSuM
CP6	5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine				PoSSuM

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Download interaction data: 3QFX

Code :

3QFX PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR

Title :

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex

Release Data :

2011-06-29

Compound :

mol_id	molecule	chains	synonym
1	Bifunctional dihydrofolate reductase-thymidylate synthase	A,B	DHFR-TS, Dihydrofolate reductase, Thymidylate synthase
	ec: 1.5.1.3 fragment: DHFR domain

Source :

mol_id	organism_scientific	expression_system
1	Trypanosoma brucei rhodesiense (taxid:31286)	Escherichia coli (taxid:562)
	gene: DHFR expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET17b

Authors :

Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.

Keywords :

pyrimethamine, antifolate resistance, Trypanosome, dihydrofolate reductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.2000 Å )

Citation :

Trypanosomal dihydrofolate reductase reveals natural antifolate resistance

Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J. et al.
(2011) Acs Chem.Biol. 6 : 905 - 911

PDB ID: 3QFX