Brand  (β version)

PDB ID: 3Q7J

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FBO L-phenylalanyl-n6-[(benzyloxy)carbonyl]-n1-hydroxy-L-lysinamide PoSSuM
Non-standard Residues
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Structure summary

Code : 3Q7J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development
Release Data : 2011-07-27
Compound :
mol_id molecule chains
1 Tricorn protease-interacting factor F3 A,B
ec: 3.4.11.-
mutation: E101Q,N261T
Source :
mol_id organism_scientific expression_system
1 Thermoplasma acidophilum  (taxid:273075) Escherichia coli  (taxid:562)
strain: DSM 1728
gene: O93655, Ta0815, trf3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET21b
Authors : Su, J., Wang, Q., Feng, J., Zhang, C., Zhu, D., We, T., Xu, W., Gu, L.
Keywords : Trf3, Inhibitor FBO, Aminopeptidase, Inhibitor binding, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.910 Å )
Citation :

Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development

Su, J.,Wang, Q.,Feng, J.  et al.
(2011)  Bioorg.Med.Chem.  19 : 2991 - 2996

PubMed: 21493078
DOI: 10.1016/j.bmc.2011.03.028

Reaction

Chain : A, B
UniProt : O93655 (TRF3_THEAC)
Reaction : -
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:15893768
Binds 1 zinc ion per subunit.