Het-PDB Navi2 (PDB: 3Q78)

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Ligands
Code	Name	Link
3CX	(2s)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid	PoSSuM
FPS	S-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl] trihydrogen thiodiphosphate	PoSSuM
ZN	Zinc ion	PoSSuM

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Download interaction data: 3Q78

Code :

3Q78 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Cryptococcus neoformans protein farnesyltransferase in complex with FSPP and DDPTASACNIQ peptide

Release Data :

2011-08-03

Compound :

mol_id	molecule	chains
1	Farnesyltransferase alpha subunit	A

mol_id	molecule	chains
2	Farnesyltransferase beta subunit	B

mol_id	molecule	chains
3	peptide substrate	D

Source :

mol_id	organism_scientific	expression_system
1	Cryptococcus neoformans (taxid:235443)	Escherichia coli (taxid:562)
	strain: H99

mol_id	organism_scientific	expression_system
2	Cryptococcus neoformans (taxid:235443)	Escherichia coli (taxid:562)
	strain: H99

mol_id	organism_scientific
3
	synthetic: yes other_details: synthetic peptide substrate

Authors :

Hast, M.A., Beese, L.S.

Keywords :

Protein prenyltransferase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.200 Å )

Citation :

Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens.

Hast, M.A.,Nichols, C.B.,Armstrong, S.M. et al.
(2011) J.Biol.Chem. 286 : 35149 - 35162

PDB ID: 3Q78