Brand  (β version)

PDB ID: 3Q61

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Ligands
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Non-standard Residues
Code Name Show
F3H 1,5-anhydro-2,3-dideoxy-3-fluoro-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-6-O-phosphono-D-altritol
Glycosylation
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Modification
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Structure summary

Code : 3Q61   PDBj   RCSB PDB   PDBe
Header : DNA
Title : 3'-Fluoro Hexitol Nucleic Acid DNA Structure
Release Data : 2012-01-18
Compound :
mol_id molecule chains
1 DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3') A,B
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: Chemically synthesized oligonucleotide
Authors : Seth, P.R., Allerson, C.R., Prakash, T.P., Siwkowski, A., Berdeja, A., Yu, J., Pallan, P.S., Watt, A.T., Gaus, H., Bhat, B., Egli, M., Swayze, E.E.
Keywords : A-FORM DNA, 3'-Fluoro Hexitol Nucleic Acid, FHNA, Antisense oligonucleotides, DNA
Exp. method : X-RAY DIFFRACTION ( 1.56 Å )
Citation :

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Egli, M.,Pallan, P.S.,Allerson, C.R.  et al.
(2011)  J.Am.Chem.Soc.  133 : 16642 - 16649

PubMed: 21919455
DOI: 10.1021/ja207086x