Brand  (β version)

PDB ID: 3PZE

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Ligands
Code Name Style Show Link
CFK 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PZE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : JNK1 in complex with inhibitor
Release Data : 2011-12-14
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 8 A MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1
ec: 2.7.11.24
fragment: UNP residues 7-364
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK8, JNK1, PRKM8, SAPK1
Authors : Xue, Y.
Keywords : kinase JNK1, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas.

Oza, V.,Ashwell, S.,Almeida, L.  et al.
(2012)  J.Med.Chem.  55 : 5130 - 5142

PubMed: 22551018
DOI: 10.1021/jm300025r

Reaction

Chain : A
UniProt : P45983 (MK08_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:10747973, PubMed:10856240, PubMed:11062067, PubMed:15141161, PubMed:16581800, PubMed:17296730, PubMed:17875713, PubMed:18307971, PubMed:19166818, PubMed:20027304, PubMed:21095239, PubMed:21364637, PubMed:21660049, PubMed:21856198, PubMed:22441692, PubMed:22966201, PubMed:27568560, PubMed:28943315, PubMed:8654373
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:10747973, PubMed:10856240, PubMed:11062067, PubMed:15141161, PubMed:16581800, PubMed:17296730, PubMed:17875713, PubMed:18307971, PubMed:19166818, PubMed:20027304, PubMed:21095239, PubMed:21364637, PubMed:21660049, PubMed:21856198, PubMed:22441692, PubMed:8654373
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