Brand  (β version)

PDB ID: 3PXU

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Ligands
Code Name Style Show Link
COD Dephospho coenzyme a PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3PXU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei bound to dephospho-coenzyme A
Release Data : 2010-12-22
Compound :
mol_id molecule chains synonym
1 Phosphopantetheine adenylyltransferase A Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT
ec: 2.7.7.3
Source :
mol_id organism_scientific expression_system
1 Burkholderia pseudomallei  (taxid:320372) Escherichia coli  (taxid:562)
strain: 1710b
gene: BURPS1710b_0748, coaD, coaD BURPS1710B_0748
expression_system_vector_type: pAVA0421
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, HUMAN AND ANIMAL PATHOGEN, MELIOIDOSIS, ATP-BINDING, COENZYME A BIOSYNTHESIS, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, TRANSFERASE, PPAT, pantetheine-phosphate adenylyltransferase
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei.

Edwards, T.E.,Leibly, D.J.,Bhandari, J.  et al.
(2011)  Acta Crystallogr.,Sect.F  67 : 1032 - 1037

PubMed: 21904046
DOI: 10.1107/S1744309111004349

Combining functional and structural genomics to sample the essential Burkholderia structome.

Baugh, L.,Gallagher, L.A.,Patrapuvich, R.  et al.
(2013)  Plos One  8 : e53851 - e53851

PubMed: 23382856
DOI: 10.1371/journal.pone.0053851

Reaction

Chain : A
UniProt : Q3JW91 (COAD_BURP1)
Reaction: EC: Evidence:
Physiological Direction:
(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate 2.7.7.3 HAMAP-Rule:MF_00151
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000255 | HAMAP-Rule:MF_00151
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