Brand  (β version)

PDB ID: 3PWD

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Ligands
Code Name Style Show Link
CZ0 8-hydroxy-4-methyl-9-nitro-2h-benzo[G]chromen-2-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PWD   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of maize CK2 in complex with NBC (Z1)
Release Data : 2011-11-02
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II, CK2-alpha
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Zea mays  (taxid:4577) Maize Escherichia coli  (taxid:562)
gene: ACK2
expression_system_vector_type: plasmid
expression_system_plasmid: pT7-7
Authors : Battistutta, R., Mazzorana, M.
Keywords : protein kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2000 Å )
Citation :

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

Sarno, S.,Mazzorana, M.,Traynor, R.  et al.
(2012)  Cell.Mol.Life Sci.  69 : 449 - 460

PubMed: 21720886
DOI: 10.1007/s00018-011-0758-7

Reaction

Chain : A
UniProt : P28523 (CSK2A_MAIZE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-