Brand  (β version)

PDB ID: 3PW4

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Ligands
Code Name Style Show Link
AFN 8,9-dihydro-9-hydroxy-aflatoxin b1 PoSSuM
CA Calcium ion PoSSuM
DTP 2'-deoxyadenosine 5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3PW4   PDBj   RCSB PDB   PDBe
Header : Transferase/DNA
Title : Ternary complex of Aflatoxin B1 Adduct modified DNA (AFB1-N7-Gua) with DNA Polymerase IV and incoming dATP
Release Data : 2011-08-10
Compound :
mol_id molecule chains synonym
1 DNA polymerase IV A Pol IV
ec: 2.7.7.7
fragment: UNP residues 1-341
mol_id molecule chains
2 DNA (5'-D(*TP*TP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3') B
other_details: Modified DNA Template
mol_id molecule chains
3 DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3') C
other_details: DNA Primer
Source :
mol_id organism_scientific organism_common expression_system
1 Sulfolobus solfataricus  (taxid:2287) Sulfolobu solfataricus Escherichia coli  (taxid:562)
gene: dbh, dpo4, SSO2448
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Banerjee, S.
Keywords : Ternary complex of Dpo4-DNA-dATP, DNA Polymerase, DNA Adduct, Transferase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV.

Banerjee, S.,Brown, K.L.,Egli, M.  et al.
(2011)  J.Am.Chem.Soc.  133 : 12556 - 12568

PubMed: 21790157
DOI: 10.1021/ja2015668

Reaction

Chain : A
UniProt : Q97W02 (DPO4_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
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