Het-PDB Navi2 (PDB: 3PSC)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
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CMT	O-methylcysteine

Glycosylation
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Download interaction data: 3PSC

Code :

3PSC PDBj RCSB PDB PDBe

Header :

TRANSFERASE/SIGNALING PROTEIN

Title :

Bovine GRK2 in complex with Gbetagamma subunits

Release Data :

2011-06-01

Compound :

mol_id	molecule	chains	synonym
1	Beta-adrenergic receptor kinase 1	A	GRK2, Beta-ARK-1, G-protein-coupled receptor kinase 2
	ec: 2.7.11.15 mutation: S670A

mol_id	molecule	chains	synonym
2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	Transducin beta chain 1

mol_id	molecule	chains	synonym
3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G	G gamma-I
	fragment: UNP residues 1-68

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bos taurus (taxid:9913)	Bovine	Spodoptera frugiperda (taxid:7108)
	gene: ADRBK1, GRK2 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Bovine	Spodoptera frugiperda (taxid:7108)
	gene: GNB1 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
3	Bos taurus (taxid:9913)	Bovine	Spodoptera frugiperda (taxid:7108)
	gene: GNG2 expression_system_common: Fall armyworm

Authors :

Thal, D.M., Tesmer, J.J.

Keywords :

Kinase, Serine/threonine-protein kinase, ATP-binding, Membrane, TRANSFERASE-SIGNALING PROTEIN complex

Exp. method :

X-RAY DIFFRACTION ( 2.67 Å )

Citation :

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.

Thal, D.M.,Yeow, R.Y.,Schoenau, C. et al.
(2011) Mol.Pharmacol. 80 : 294 - 303

PDB ID: 3PSC