Brand  (β version)

PDB ID: 3PR2

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Ligands
Code Name Style Show Link
7MN (z)-N-[(1e)-1-carboxy-2-(2,3-dihydro-1h-indol-1-yl)ethylidene]{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1h)-ylidene}methanaminium PoSSuM
CS Cesium ion PoSSuM
F9F 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PR2   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site
Release Data : 2011-02-09
Compound :
mol_id molecule chains
1 Tryptophan synthase alpha chain A
ec: 4.2.1.20
mol_id molecule chains
2 Tryptophan synthase beta chain B
ec: 4.2.1.20
Source :
mol_id organism_scientific expression_system
1 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
gene: STM1727, trpA
expression_system_strain: Cb149
expression_system_vector_type: plasmid
expression_system_plasmid: pSTB7
mol_id organism_scientific expression_system
2 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
gene: STM1726, trpB
expression_system_strain: Cb149
expression_system_vector_type: plasmid
expression_system_plasmid: pSTB7
Authors : Lai, J., Niks, D., Wang, Y., Domratcheva, T., Barends, T.R.M., Schwarz, F., Olsen, R.A., Elliott, D.W., Fatmi, M.Q., Chang, C.A., Schlichting, I., Dunn, M.F., Mueller, L.J.
Keywords : alpha-beta barrel, TIM-barrel, tryptophan synthesis, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

X-ray and NMR Crystallography in an Enzyme Active Site: The Indoline Quinonoid Intermediate in Tryptophan Synthase.

Lai, J.,Niks, D.,Wang, Y.  et al.
(2011)  J.Am.Chem.Soc.  133 : 4 - 7

PubMed: 21142052
DOI: 10.1021/ja106555c

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 HAMAP-Rule:MF_00131
-
Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 -
-