Het-PDB Navi2 (PDB: 3PQZ)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
CCS	Carboxymethylated cysteine

Glycosylation
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Download interaction data: 3PQZ

Code :

3PQZ PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING

Title :

Grb7 SH2 with peptide

Release Data :

2011-07-20

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 7	A,B,C,D	B47, Epidermal growth factor receptor GRB-7, GRB7 adapter protein
	fragment: SH2 domain

mol_id	molecule	chains
2	cyclic peptide	L,M

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRB7 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pGEX

mol_id	organism_scientific
2
	synthetic: yes other_details: Sequence designed by Phase Display. Peptide was made synthetically

Authors :

Wilce, J.A.

Keywords :

SH2, binds phosphotyrosine, tyrosine kinases, cytoplasmic, PROTEIN BINDING

Exp. method :

X-RAY DIFFRACTION ( 2.4130 Å )

Citation :

Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression

Ambaye, N.D.,Pero, S.C.,Gunzburg, M.J. et al.
(2011) J.Mol.Biol. 412 : 397 - 411

PDB ID: 3PQZ