Het-PDB Navi2 (PDB: 3PP0)

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Ligands
Code	Name		Style	Show	Link
03Q	2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-D]pyrimidin-5-yl]ethoxy}ethanol				PoSSuM

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Download interaction data: 3PP0

Code :

3PP0 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal Structure of the Kinase domain of Human HER2 (erbB2).

Release Data :

2011-03-30

Compound :

mol_id	molecule	chains	synonym
1	Receptor tyrosine-protein kinase erbB-2	A,B	Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2
	ec: 2.7.10.1 fragment: kinase domain, residues 706-1009 mutation: M706A, Q711L, M712L

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7118)
	gene: ERBB2, HER2, MLN19, NEU, NGL expression_system_common: Fall armyworm expression_system_cell_line: Sf9 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: pFastBac1

Authors :

Skene, R.J., Aertgeerts, K., Sogabe, S.

Keywords :

KINASE DOMAIN, ANTI-ONCOGENE, ATP-BINDING, CELL CYCLE, DISEASE MUTATION, GLYCOPROTEIN, MEMBRANE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, RECEPTOR, SECRETED, TRANSFERASE, TRANSMEMBRANE, TYROSINE-PROTEIN KINASE, TYROSINE KINASE INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.25 Å )

Citation :

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein.

Aertgeerts, K.,Skene, R.,Yano, J. et al.
(2011) J.Biol.Chem. 286 : 18756 - 18765

PubMed: 21454582
DOI: 10.1074/jbc.M110.206193

Chain :

A, B

UniProt :

P04626 (ERBB2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:21454582
	-	PROSITE-ProRule:PRU10028, PubMed:21454582

PDB ID: 3PP0

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Structure summary

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