Brand  (β version)

PDB ID: 3PN1

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Ligands
Code Name Style Show Link
IVH 2-(butylsulfanyl)adenosine PoSSuM
IWH 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PN1   PDBj   RCSB PDB   PDBe
Header : Ligase/Ligase Inhibitor
Title : Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo
Release Data : 2011-01-12
Compound :
mol_id molecule chains synonym
1 DNA ligase A Polydeoxyribonucleotide synthase [NAD+]
ec: 6.5.1.2
fragment: Adenylation Domain
Source :
mol_id organism_scientific expression_system
1 Haemophilus influenzae  (taxid:727) Escherichia coli  (taxid:562)
gene: ligA, lig, ligN, HI_1100
Authors : Mills, S., Eakin, A., Buurman, E., Newman, J., Gao, N., Huynh, H., Johnson, K., Lahiri, S., Shapiro, A., Walkup, G., Wei, Y., Stokes, S.
Keywords : ATP grasp fold, ligase, DNA, bacteria, Ligase-Ligase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo.

Mills, S.D.,Eakin, A.E.,Buurman, E.T.  et al.
(2011)  Antimicrob.Agents Chemother.  55 : 1088 - 1096

PubMed: 21189350
DOI: 10.1128/AAC.01181-10

Reaction

Chain : A
UniProt : P43813 (DNLJ_HAEIN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta- nicotinamide D-nucleotide. 6.5.1.2 HAMAP- Rule:MF_01588
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