Het-PDB Navi2 (PDB: 3PMH)

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Ligands
Code	Name		Style	Show	Link
0G7	D-phenylalanyl-N-[(3s)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 3PMH

Code :

3PMH PDBj RCSB PDB PDBe

Header :

blood cloting, hydrolase/inhibitor

Title :

Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites

Release Data :

2011-06-01

Compound :

mol_id	molecule	chains	synonym
1	THROMBIN ALPHA-CHAIN	A	Coagulation factor II
	ec: 3.4.21.5

mol_id	molecule	chains	synonym
2	THROMBIN BETA-CHAIN	B	Coagulation factor II
	ec: 3.4.21.5

mol_id	molecule	chains
3	Platelet glycoprotein Ib alpha chain	G
	fragment: unp residues 17-306 mutation: C65A

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	other_details: From human plasma

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	other_details: From human plasma

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Drosophila melanogaster (taxid:7227)
	gene: GP1BA, platelet glycoprotein Ib alpha

Authors :

Varughese, K.I., Celikel, R.

Keywords :

Sulfated tyrosine residues, Leucine Rich Repeats, Protease Platelet receptor of thrombin, Thrombin binding, Platelet surface, blood cloting, hydrolase-inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 3.20 Å )

Citation :

Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.

Zarpellon, A.,Celikel, R.,Roberts, J.R. et al.
(2011) Proc.Natl.Acad.Sci.USA 108 : 8628 - 8633

PubMed: 21555542
DOI: 10.1073/pnas.1017042108

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	G
UniProt :	P07359 (GP1BA_HUMAN)
Reaction :	-

PDB ID: 3PMH

Hetero Atom Contents

Structure summary

Reaction