Brand  (β version)

PDB ID: 3PJ2

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Ligands
Code Name Style Show Link
04K 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-D]pyrimidin-7(8h)-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PJ2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-D]pyrimidin-7-one
Release Data : 2011-01-12
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase BTK A Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase
ec: 2.7.10.2
fragment: unp residues 387-659
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: AGMX1, ATK, BPK, BTK
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: baculovirus
Authors : Kuglstatter, A., Wong, A.
Keywords : helix C-out, DFG-in, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.

Kuglstatter, A.,Wong, A.,Tsing, S.  et al.
(2011)  Protein Sci.  20 : 428 - 436

PubMed: 21280133
DOI: 10.1002/pro.575

Reaction

Chain : A
UniProt : Q06187 (BTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:11606584, PubMed:34554188
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