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Ligands
Code Name Style Show Link
F41 N-(1,3-benzodioxol-5-yl)-2-(piperidin-1-yl)acetamide
GOL Glycerol
Non-standard Residues
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Glycosylation
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Code : 3PGI   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Endothiapepsin in complex with a fragment
Release Data : 2011-10-26
Compound :
mol_id molecule chains synonym
1 Endothiapepsin A Aspartate protease
ec: 3.4.23.22
Source :
mol_id organism_scientific organism_common
1 Cryphonectria parasitica  (taxid:5116) Chesnut blight fungus
Authors : Koester, H., Heine, A., Klebe, G.
Keywords : HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes.

Koster, H.,Craan, T.,Brass, S.  et al.
(2011)  J.Med.Chem.  54 : 7784 - 7796

PubMed: 21972967
DOI: 10.1021/jm200642w

Chain : A
UniProt : P11838 (CARP_CRYPA)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins with specificity similar to that of pepsin A, prefers hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk. 3.4.23.22 -
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