Brand  (β version)

PDB ID: 3PFP

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Ligands
Code Name Style Show Link
035 (2s)-2,7-bis(phosphonooxy)heptanoic acid PoSSuM
036 (2r)-2,7-bis(phosphonooxy)heptanoic acid PoSSuM
CL Chloride ion PoSSuM
MN Manganese (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3PFP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Release Data : 2011-03-16
Compound :
mol_id molecule chains synonym
1 Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG A,B DAHP synthetase, phenylalanine-repressible
ec: 2.5.1.54
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: aroG, Rv2178c
expression_system_vector_type: plasmid
expression_system_plasmid: pProExHTa
Authors : Reichau, S., Jiao, W., Walker, S.R., Hutton, R.D., Parker, E.J., Baker, E.N.
Keywords : Shikimate pathway, Mycobacterium tuberculosis, DAH7P synthase, Aromatic biosynthesis, TIM barrel, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3500 Å )
Citation :

Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design

Reichau, S.,Jiao, W.,Walker, S.R.  et al.
(2011)  J.Biol.Chem.  286 : 16197 - 16207

PubMed: 21454647
DOI: 10.1074/jbc.M110.211649

Reaction

Chain : A, B
UniProt : O53512 (AROG_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 PubMed:16288916
left-to-right
Cofactor: Evidence: Note:
Cd(2+) ECO:0000269 | PubMed:16288916
ECO:0000269 | PubMed:16288916
ECO:0000269 | PubMed:16288916
Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.