Brand  (β version)

PDB ID: 3PEQ

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Ligands
Code Name Style Show Link
3EQ [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid PoSSuM
IOD Iodide ion PoSSuM
JZR Hexyl beta-D-glucopyranoside PoSSuM
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Structure summary

Code : 3PEQ   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/TRANSCRIPTION agonist
Title : PPARd complexed with a phenoxyacetic acid partial agonist
Release Data : 2011-10-12
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor delta A,B PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta
fragment: unp residues 171-441
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: NR1C2, PPARB, PPARD
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pRSETA
Authors : Lambert, M.H., Evans, K.A., Shearer, B.G., Wisnoski, D.D., Shi, D., Jin, J., Rivero, R.A., Sparks, S.M., Winegar, D.A., Billin, A.N., Britt, C., Way, J.M., Leesnitzer, L.M., Merrihew, R.V.
Keywords : PPAR nuclear receptor, TRANSCRIPTION-TRANSCRIPTION agonist complex
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Phenoxyacetic acid PPARd partial agonists for the treatment of type 2 diabetes: synthesis, optimization, and in vivo efficacy

Evans, K.A.,Shearer, B.G.,Wisnoski, D.D.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 2345 - 2350

PubMed: 21414782
DOI: 10.1016/j.bmcl.2011.02.077

Reaction

Chain : A, B
UniProt : Q03181 (PPARD_HUMAN)
Reaction : -