Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
C72 2-(4-chlorophenyl)-4-[(3s)-piperidin-3-ylamino]thieno[3,2-C]pyridine-7-carboxamide
GOL Glycerol
Code : 3PA4
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : X-ray crystal structure of compound 2a bound to human CHK1 kinase domain
Release Data : 2010-12-08
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase Chk1 A
ec: 2.7.11.1
fragment: UNP Residues 2-274
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: CHEK1, CHK1
expression_system_strain: SF9
expression_system_vector_type: Baculovirus
Authors : Fischmann, T.O.
Keywords : kinase, phosphatase, transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.59 Å )
Citation :

Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.

Zhao, L.,Zhang, Y.,Dai, C.  et al.
(2010)  Bioorg.Med.Chem.Lett.  20 : 7216 - 7221

PubMed: 21074424
DOI: 10.1016/j.bmcl.2010.10.105

Chain : A
UniProt : O14757 (CHK1_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.