Brand  (β version)

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Modified Residues
Code Name Link
CFZ 2'-deoxy-2'-fluorocytidine 5'-(dihydrogen phosphate)
GF2 2'-deoxy-2'-fluoroguanosine 5'-(dihydrogen phosphate)
Code : 3P4D
Header : RNA
Title : Alternatingly modified 2'Fluoro RNA octamer f/rC4G4
Release Data : 2011-01-05
Compound :
mol_id molecule chains
1 5'-R(*(CFZ)P*CP*(CFZ)P*CP*(GF2)P*GP*(GF2)P*G)-3' A,B
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: Chemically synthesized modified RNA octamer
Authors : Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Keywords : RNA, 2'-FLUORO-RNA, O2'-MODIFICATION, OCTAMER, 2'-fluoro 2'-deoxycytidine, 2'-fluoro 2'-deoxyguanosine, siRNA
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.

Pallan, P.S.,Greene, E.M.,Jicman, P.A.  et al.
(2011)  Nucleic Acids Res.  39 : 3482 - 3495

PubMed: 21183463
DOI: 10.1093/nar/gkq1270