Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
SR Strontium ion
Modified Residues
Code Name Link
AF2 2'-deoxy-2'-fluoroadenosine 5'-(dihydrogen phosphate)
CFZ 2'-deoxy-2'-fluorocytidine 5'-(dihydrogen phosphate)
UFT 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate)
Code : 3P4C
Header : RNA
Title : Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-R32
Release Data : 2011-01-05
Compound :
mol_id molecule chains
1 5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3' A,B
Source :
mol_id organism_scientific
1 Synthetic construct  (taxid:32630)
synthetic: yes
other_details: Chemically synthesized modified RNA
Authors : Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Keywords : RNA, 2'-FLUORO-RNA O2'-MODIFICATION, OCTAMER, 2'-fluoro 2'-deoxycytidine, 2'-fluoro 2'-deoxyadenosine, 2'-fluoro 2'-deoxyuridine, siRNA
Exp. method : X-RAY DIFFRACTION ( 1.15 Å )
Citation :

Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.

Pallan, P.S.,Greene, E.M.,Jicman, P.A.  et al.
(2011)  Nucleic Acids Res.  39 : 3482 - 3495

PubMed: 21183463
DOI: 10.1093/nar/gkq1270