Het-PDB Navi2 (PDB: 3P3I)

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Ligands
Code	Name		Style	Show	Link
FAH	Fluoroacetic acid				PoSSuM
COA	Coenzyme a				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3P3I

Code :

3P3I PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA

Release Data :

2010-10-20

Compound :

mol_id	molecule	chains
1	Fluoroacetyl coenzyme A thioesterase	A,B,C,D,E,F
	mutation: F36A

Source :

mol_id	organism_scientific	expression_system
1	Streptomyces cattleya (taxid:29303)	Escherichia coli (taxid:562)
	gene: flK

Authors :

Weeks, A.M., Coyle, S.M., Jinek, M., Doudna, J.A., Chang, M.C.Y.

Keywords :

hot dog-fold, thioesterase, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.000 Å )

Citation :

Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.

Weeks, A.M.,Coyle, S.M.,Jinek, M. et al.
(2010) Biochemistry 49 : 9269 - 9279

Chain :

A, B, C, D, E, F

UniProt :

Q1EMV2 (FLK_STRCT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)	3.1.2.29	PubMed:16720268, PubMed:20836570
fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)	-	PubMed:16720268, PubMed:20836570

PDB ID: 3P3I