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Ligands
Code Name Style Show Link
CA Calcium ion
CL Chloride ion
FSC Fusicoccin
MG Magnesium ion
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
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Modification
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Code : 3P1Q   PDBj   RCSB PDB   PDBe
Header : PEPTIDE BINDING PROTEIN
Title : Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
Release Data : 2011-10-12
Compound :
mol_id molecule chains synonym
1 14-3-3 protein sigma A Stratifin, Epithelial cell marker protein 1
mutation: C38N,N166H
mol_id molecule chains synonym
2 6-mer peptide from Potassium channel subfamily K member 9 P TASK-3 peptide
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SFN
expression_system_strain: Rosetta DE3
expression_system_vector_type: Plasmid
expression_system_plasmid: pPROEX HTB
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence occurs naturally in humans.
Authors : Anders, C., Higuchi, Y., Schumacher, B., Thiel, P., Kato, N., Ottmann, C.
Keywords : Helical protein, Phosphoprotein, Adapter protein, Peptide binding protein, Nucleus
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface

Anders, C.,Higuchi, Y.,Koschinsky, K.  et al.
(2013)  Chem. Biol.  20 : 583 - 593

PubMed: 23601647
DOI: 10.1016/j.chembiol.2013.03.015

Chain : A
UniProt : P31947 (1433S_HUMAN)
Reaction : -
Chain : P
UniProt : Q9NPC2 (KCNK9_HUMAN)
Reaction : -