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Ligands
Code Name Style Show Link
FSE 3,7,3',4'-tetrahydroxyflavone
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Code : 3P0H   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form
Release Data : 2011-03-23
Compound :
mol_id molecule chains
1 Tyrosyl-tRNA synthetase A,B
ec: 6.1.1.1
Source :
mol_id organism_scientific expression_system
1 Leishmania major  (taxid:5664) Escherichia coli  (taxid:562)
gene: LmjF14.1370
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: BG1861
Authors : Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Keywords : aminoacyl-tRNA synthetase, tRNA ligase, aaRS, TyrRS, pseudodimer, translation, ATP-binding, nucleotide-binding, Structural Genomics, Medical Structural Genomics of Pathogenic Protozoa, MSGPP, LIGASE
Exp. method : X-RAY DIFFRACTION ( 3.0000 Å )
Citation :

The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.

Larson, E.T.,Kim, J.E.,Castaneda, L.J.  et al.
(2011)  J.Mol.Biol.  409 : 159 - 176

PubMed: 21420975
DOI: 10.1016/j.jmb.2011.03.026

Chain : A, B
UniProt : Q4QFJ7 (Q4QFJ7_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L- tyrosyl-tRNA(Tyr) 6.1.1.1 ARBA:ARBA00000069
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