Brand  (β version)

PDB ID: 3OXX

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
EDO 1,2-ethanediol PoSSuM
ACT Acetate ion PoSSuM
DR7 (3s,8s,9s,12s)-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5, 6,10,13-pentaazatetradecanedioic acid dimethyl ester PoSSuM
Non-standard Residues
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Structure summary

Code : 3OXX   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir
Release Data : 2011-09-28
Compound :
mol_id molecule chains synonym
1 HIV-1 PROTEASE B,A,C,D Retropepsin, PR
ec: 3.4.23.16
mutation: Q7K, I50V, A71V
Source :
mol_id organism_scientific organism_common expression_system
1 HIV-1 M:B_ARV2/SF2  (taxid:11685) HIV-1 Escherichia coli  (taxid:562)
strain: SF2
gene: gag-pol
expression_system_strain: TAP106
expression_system_vector_type: plasmid
expression_system_plasmid: pXC35
Authors : Schiffer, C.A., Bandaranayake, R.M.
Keywords : HIV-1 protease, inhibitor resistance, AIDS, Aspartyl protease, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.

Mittal, S.,Bandaranayake, R.M.,King, N.M.  et al.
(2013)  J.Virol.  87 : 4176 - 4184

PubMed: 23365446
DOI: 10.1128/JVI.03486-12

Reaction

Chain : B, A, C, D
UniProt : P03369 (POL_HV1A2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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