Brand  (β version)

PDB ID: 3OUH

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Ligands
Code Name Style Show Link
014 1-(5-chloro-6-fluoro-1h-benzimidazol-2-yl)-1h-pyrazole-4-carboxylic acid PoSSuM
FE2 Fe (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3OUH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : PHD2-R127 with JNJ41536014
Release Data : 2010-12-01
Compound :
mol_id molecule chains synonym
1 Egl nine homolog 1 A Hypoxia-inducible factor prolyl hydroxylase 2, HIF-prolyl hydroxylase 2, HIF-PH2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20
ec: 1.14.11.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: EGLN1, C1orf12, PNAS-118, PNAS-137
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PBAD-SMT
Authors : Kim, H., Clark, R.
Keywords : PHD2, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.51 Å )
Citation :

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.

Rosen, M.D.,Venkatesan, H.,Peltier, H.M.  et al.
(2010)  ACS Med Chem Lett  1 : 526 - 529

PubMed: 24900242
DOI: 10.1021/ml100198y

Reaction

Chain : A
UniProt : Q9GZT9 (EGLN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- inducible factor alpha subunit] 1.14.11.29 PubMed:25129147
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