Brand  (β version)

PDB ID: 3ONI

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Ligands
Code Name Style Show Link
JQ1 (6s)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium PoSSuM
NI Nickel (II) ion PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 3ONI   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor JQ1
Release Data : 2010-10-06
Compound :
mol_id molecule chains synonym
1 Bromodomain containing 2, isoform CRA_a A Putative uncharacterized protein DKFZp313H139
fragment: residues 224-335
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: BRD2, DKFZp313H139, hCG_17503
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Picaud, S., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bradner, J.E., Structural Genomics Consortium (SGC)
Keywords : Structural Genomics, Structural Genomics Consortium, SGC, Bromodomain, Inhibition, Probe, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 1.6100 Å )
Citation :

Selective inhibition of BET bromodomains.

Filippakopoulos, P.,Qi, J.,Picaud, S.  et al.
(2010)  Nature  468 : 1067 - 1073

PubMed: 20871596
DOI: 10.1038/nature09504

Reaction

Chain : A
UniProt : Q658Y7 (BRD2_HUMAN)
Reaction : -