Brand  (β version)

PDB ID: 3OCN

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Ligands
Code Name Style Show Link
CTJ 1-({(2r)-2-[(1r)-1-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2h-1,3-thiazin-5-yl}methyl)pyridinium PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3OCN   PDBj   RCSB PDB   PDBe
Header : PENICILLIN-BINDING PROTEIN/ANTIBIOTIC
Title : Crystal structure of penicillin-binding protein 3 from Pseudomonas aeruginosa in complex with ceftazidime
Release Data : 2010-11-10
Compound :
mol_id molecule chains
1 penicillin-binding protein 3 A
fragment: residues in UNP 35-579
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:562)
strain: PAO1
gene: PA4418
expression_system_strain: DE3
expression_system_vector_type: PLASMID
expression_system_plasmid: OPPF6502
Authors : Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Keywords : penicillin-binding proteins, Pseudomonas aeruginosa, ceftazidime, Structural Genomics, Oxford Protein Production Facility, OPPF, transpeptidase, cell wall biosynthesis, out periplasmic membrane, PENICILLIN-BINDING PROTEIN-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms

Sainsbury, S.,Bird, L.,Rao, V.  et al.
(2011)  J.Mol.Biol.  405 : 173 - 184

PubMed: 20974151
DOI: 10.1016/j.jmb.2010.10.024

Reaction

Chain : A
UniProt : Q51504 (Q51504_PSEAI)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 3.4.16.4 HAMAP- Rule:MF_02080
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