Brand  (β version)

PDB ID: 3O6O

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
94M 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9h-purin-2-amine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3O6O   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021
Release Data : 2010-08-18
Compound :
mol_id molecule chains
1 Heat shock protein 83 A,B
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei  (taxid:5691) Escherichia coli  (taxid:562)
gene: Tb10.26.1080
expression_system_strain: BL21(DE3)V2rPrare2
expression_system_vector_type: plasmid
expression_system_plasmid: pet15
Authors : Wernimont, A.K., Hutchinson, A., Sullivan, H., Weadge, J., Li, Y., Kozieradzki, I., Cossar, D., Bochkarev, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Wyatt, P., Fairlamb, A.H., Ferguson, M.A.J., Thompson, S., MacKenzie, C., Hui, R., Pizarro, J.C., Hills, T., Structural Genomics Consortium (SGC)
Keywords : Trypanosoma, African Sleeping sickness, heat shock protein, Structural Genomics, Structural Genomics Consortium, SGC, CHAPERONE
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

Pizarro, J.C.,Hills, T.,Senisterra, G.  et al.
(2013)  PLoS Negl Trop Dis  7 : e2492 - e2492

PubMed: 24147171
DOI: 10.1371/journal.pntd.0002492

Reaction

Chain : A, B
UniProt : Q389P1 (Q389P1_TRYB2)
Reaction : -