Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CA Calcium ion
CAQ Catechol
Code : 3O4M
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene
Release Data : 2010-08-25
Compound :
mol_id molecule chains synonym
1 Phospholipase A2, major isoenzyme A Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2
ec: 3.1.1.4
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
tissue: Pancreas
Authors : Dileep, K.V., Tintu, I., Karthe, P., Mandal, P.K., Haridas, M., Sadasivan, C.
Keywords : Catechol binding, PLA2, Pancreatic Enzyme, Disulfide bond, Lipid degradation, Lipoprotein, Metal-binding, Palmitate, Pyrrolidone carboxylic acid, Pancreas, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Binding to PLA(2) may contribute to the anti-inflammatory activity of catechol

Dileep, K.V.,Tintu, I.,Mandal, P.K.  et al.
(2011)  Chem.Biol.Drug Des. 

PubMed: 21995306
DOI: 10.1111/j.1747-0285.2011.01258.x

Chain : A
UniProt : P00592 (PA21B_PIG)
Reaction : Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.